Fig. 7
A graphical abstract of performed experiment. Upregulation of miR-21-5p regulates the dynamic of mitochondria network, thus, positively affects the proper mineralization of extracellular matrix in BMSCSAM/P6 and accumulation of proteins crucial for bone homeostasis maintenance. MiR-21 decreases the deteriorated autophagy and regulates mitochondrial network dynamic in BMSCs. In vivo study confirms the results obtained during ex vivo experiments, evidenced by enhanced bone regeneration and greater accumulation of Ca and P. All images and illustrations depicted in this figure were prepared by the Authors