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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Single-stage transplantation combined with epidermal stem cells promotes the survival of tissue-engineered skin by inducing early angiogenesis

Fig. 5

EpSCs improved ADM wound healing and promoted the survival of one-step tissue-engineered skin grafts. A, B HE and Masson staining of the skin. Scale bar: 1 mm. The black dotted line delimits its borders. A indicates acellular dermal matrix (ADM), N indicates normal skin, S indicates STSG skin, and W indicates wound skin.* indicates a hair follicle. C Ratio of the new epidermis thickness to the normal epidermis thickness. The red dotted line shows the thickness of the normal epidermis. D Skin thickness of each group at 3 weeks after surgery (n = 3). E Count of skin appendages/LPF. F Collagen volume fraction (CVF) of each group at 3 weeks after surgery (n = 3). G Comparison of K10 staining in AE and ADM groups 3 and 6 weeks after surgery. K10:red, DAPI: blue. Scale bar: 50 μm. H K10-positive area (%) of ADM and AE groups. I Representation of rat EGFP-EpSCs in the hair follicle structures. EpSCs Green, DAPI Blue. Scale bar: 10 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512