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Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A

Fig. 10

Astrocytes influence NSC differentiation and NSC–NSC communication. A Inflammation following SCI stimulated astrocytes to release more BMP2. B BMP2 promoted the differentiation of NSCs into astrocytes and enriches miRNA-22 within EVs derived from NSCs. C In the early phase of SCI, BMP2 accumulated around the cavity and remained at a relatively high level; it had a stronger effect on the regulation of NSC differentiation than miRNA-22. Therefore, in this period, NSCs differentiated into astrocytes, forming astrocytic barriers limiting the spread of inflammation. D With time, the expression of miRNA-22 increased with the decrease in BMP2, and the BMP2-induced effect in regulating the differentiation of NSCs weakened gradually. When the BMP2-induced effect was weaker than that of miRNA-22, NSCs differentiated into oligodendrocytes, promoting axon regrowth and remyelination

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Stem Cell Research & Therapy

ISSN: 1757-6512