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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions

Fig. 2

Relationships among GSCs, NSCs and microglia and physiological outcomes of NSCs. NSCs in SVZ induce high-grade glioma to invade SVZ by secreting specific chemokines like CXCL12, some proteins like PTN that regulate cell migration. And they play a key role in migration of GSCs from tumor masses to SVZ. Microglia also play an important role in the microenvironment of GSCs and NSCs. SVZ is the largest repository of adult NSCs. Under physiological conditions, NSCs differentiate into neurons, oligodendrocytes, and astrocytes. Clinically, NSCs of SVZ transformed into oligodendrocytes are more likely to develop into GBM. Schematic created with Adobe Illustrator

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Stem Cell Research & Therapy

ISSN: 1757-6512