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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration

Fig. 6

Effect of selected miRNAs in Thy1-MC EVs on SH proliferation. Photos indicate SH colonies transfected with miR-125b-5p, miR-145-5p, miR-199a-5p, and miR-451-5p mimics, which were added to the culture medium for 2 days (A). The cells were cultured until day 7, and BrdU was added to the culture medium 24 h before fixation. Immunostaining was performed using BrdU. Scale bar, 100 μm. B Total number of SH colonies per well, C number of cells per colony, and D percentage of BrdU+ cells per colony (E). Asterisk indicates significant differences compared with the control at p < 0.05

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