Fig. 4

In vitro wound healing properties of MSCs. a BM-CM displayed superior ability to induce endothelial cell migration in an in vitro wound healing model at 8 and 24 h after injury. b Representative phase contrast images at time 24 h after scratch; yellow lines show wound width at time 0 h and white lines at time 8 h after scratch. Increased wound gap can be observed at 24 h in the negative control due to cell death, when HUVECs are grown with serum-free MEM-α. Data displayed as mean ± SD, N = 3, n = 3. Two-way ANOVA with Tukey’s multiple comparison corrections, *p < 0.05, **p < 0.001, **p < 0.0001, ****p < 0.00001. ^#Significance relative to negative control