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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation

Fig. 2

Metformin promotes FGSC proliferation in vitro. A Cellular morphology of FGSCs treated with various concentrations (I: control, II: 0.01 μM, III: 0.1 mM, IV: 1 μM, V: 10 μM, VI: 100 μM) of metformin (Scale bars: 20 µm). B Cells were counted after metformin treatment at various concentrations. C Cell viability assay after treatment with various metformin concentrations. D, E Cell proliferation after metformin treatment at various concentrations. (EdU, red; Hoechst 33,342, blue). (Scale bars: 20 μm). Right: Statistical analysis of EdU-positive cells. All data are presented as means ± SD of three biological replicates. *p < 0.05, **p < 0.01 compared with the control by one-way ANOVA and the multiple comparison test. Con: control

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Stem Cell Research & Therapy

ISSN: 1757-6512