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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation

Fig. 7

CDR3 V-segment and J-segment analyses and functionality in the trafficked maternal (MMc) and recipients of IUT groups. Similarities in variable V-segment and joining J-segment usage were observed between pIUT, DC-depleted pIUT and mIUT recipient-derived clonotypes and DC-depleted pIUT MMc-derived clonotypes, with upregulated IGH, IGK, TRA, TRB V- and J-segments, and TRG and TRD J-segments; TRA J-segments were downregulated (a). CDR3 amino acid sequences of the top 20 shared clonotypes demonstrated motif enrichment (listed in b) corresponding to Ras GTPase activating proteins, mitogen-activated protein kinases (MAPK) substrates, and signal transduction molecules, among others

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