Fig. 1

Overview of the erythropoiesis process which provides the production of mature red blood cells. Erythropoiesis can be divided into two stages of differentiation. In the first, known as early erythroid differentiation stage, hematopoietic stem cells (HSCs), located in the bone marrow, differentiate first into common myeloid progenitors and then into proerythroblasts. In the second, known as late erythroid differentiation stage, proerythroblasts become in sequence basophilic, polychromatic and orthochromatic erythroblasts, upon erythropoietin stimulation. Upon expelling nuclei and losing all organelles, orthochromatic erythroblasts become reticulocytes. Lastly, reticulocytes are then released into the circulation and begin their maturation to become functional red blood cells. Figure was made by the authors of this review by using BioRender online tool (www.biorender.com). Figure is not under copyright