Skip to main content

Table 1 Clinical indication and application in cell therapy

From: Cell therapy in end-stage liver disease: replace and remodel

Cell type

Clinical indication

Clinical application

References

Hepatocyte

IEM

Yes

[33,34,35, 41]

Crigler–Najjar syndrome type I

Yes

[36]

ALF

Yes

[48,49,50, 52, 55, 56, 190]

ACLF

Yes

[60, 61]

PSC

uPA immunodeficient

No

[87]

Macrophage

Liver fibrosis

Yes

[146, 147]

MSC

Liver fibrosis, chronic liver disease, ACLF

Yes

[117,118,119]

Haematopoietic progenitor cell

Liver fibrosis

Some clinical reports and small number of randomized trials

[172,173,174]

  1. IEM inborn errors of metabolism, ALF acute liver failure, ACLF acute-on-chronic liver failure, PSC pluripotent stem cell, uPA urokinase-type plasminogen activator