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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Fig. 4

Obesity/dyslipidemia associates with dysregulated 5hmC levels in swine MSCs on genes related to apoptotic process. A Volcano plot showing differential 5hmC levels in Obese- versus Lean-MSCs for genes filtered by the Gene Ontology (GO) term for apoptotic process (GO:0006915). For a given gene, differential 5hmC levels entail p-value ≤ 0.05 and fold change (Obese-MSCs/Lean-MSCs) ≥ 1.4 (high 5hmC levels) or ≤ 0.7 (low 5hmC levels). Genes with high (n = 58) or low (n = 46) 5hmC levels in Obese-MSCs versus Lean-MSCs are represented with red or blue markers, respectively. High 5hmC genes with undetectable 5hmC levels in Lean-MSCs are presented as outliers (red triangles). B Heat map of genes filtered by apoptotic process (GO:0006915) showing higher (left) or lower (right) 5hmC levels in Obese-MSCs versus Lean-MSCs. C Venn diagram analysis shows regulators of apoptotic process among genes with higher (left) or lower (right) 5hmC levels in Obese- versus Lean-MSCs, grouped based on GO terms: positive (GO:0043065) and negative (GO:0043066) regulation of apoptotic process

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Stem Cell Research & Therapy

ISSN: 1757-6512