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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome

Figure 1

The reprogramming cells show a similar morphology to hESCs. (A) One induced pluripotent stem cell (iPSC) line derived from a Down syndrome (DS) patient with translocation (DS/translocation). Morphology of the parental human dermal fibroblasts (HDFs; left), iPSC1 (colony no.1 reprogrammed from HDFs-DS/translocation) before picking the colony (middle), and at passage 8 (right). (B) Two iPSC lines derived from a DS patient with trisomy 21 (DS/trisomy 21). Morphology of the parental HDFs (left), iPSCs 2 (Colony No. 2 reprogrammed from HDFs-DS/trisomy 21) and iPSC4 (Colony No. 4 reprogrammed from HDFs-DS/trisomy 21) before picking the colonies (middle), and at passage 5 (right). Scale bars, 100 μm.

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Stem Cell Research & Therapy

ISSN: 1757-6512