Figure 1

CD34+-enriched mononuclear cells increase angiogenesis in sponges. Impregnation of sponges with CD34+-enriched MNC (mononuclear cells) from (A) granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood or (B) umbilical cord blood, significantly increased vascular density within sponges compared to contralateral sponges without cells. CD34+-enriched MNC from bone marrow (C) and CD34+-depleted cells from any source had no effect. The replicate means of paired Chalkley counts are shown for all mice receiving each kind of cell fraction from each source. The data are pooled from different experiments where different donors contributed to sets of enriched and depleted cells. Data were analyzed comparing individual count results for sponge pairs from each mouse (n = number of mice) for each cell type and source by repeat-measure analysis of variance.