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Table 1 Summary of clinical studies conducted using bone marrow-derived mesenchymal stem cells in patients with osteoarthritis

From: Mesenchymal stem cells for cartilage repair in osteoarthritis

Study number Authors or institution Number of subjects Type of study Cell type and dose used Efficacy parameters Outcome Duration offollow-up Referenceor Clinical-Trials. govidentifier
1 Kuroda et al., 2007 [40] 1 Case report Autologous BM-MSCs + collagen gel Arthroscopy and HPE Defect filled with hyaline-like type of cartilage tissue 1 year [40]
2 Wakitani et al., 2007 [41] 3 Case series Autologous BM-MSCs (5 million) + collagen sheet HPE and MRI Histology: defect repaired with fibrocartilaginous tissue MRI: complete coverage of defect 1 year [41]
3 Osiris Therapeutics, Inc. (Columbia, MD, USA), 2007 55 Randomized double-blind Allogeneic BM-MSCs (50 and 150 million) VAS pain score and MRI VAS: Significantly reduced pain MRI: Decreased degenerative bone changes 2 years [46, 47]
4 Centeno et al., 2008 [45] 1 IRB-approved study Autologous BM-MSCs (22.4 million) + 1 mL of nucleated cells + 1 mL of 10% platelets VAS pain score and MRI knee joint Decreased VAS score MRI: increase in meniscus and femoral cartilage volume 24 weeks [45]
5 Nejadnik et al., 2010 [39] 72 Observational cohort study Autologous BM-MSCs: n = 36; Chondrocytes: n = 36 ICRS Cartilage Injury Evaluation Package Improvement in physical role functioning in BM-MSCs 2 years [39]
6 Davatchi et al., 2011 [44] 4 IRB-approved study Autologous BM-MSCs (8 to 9 million) Walking time for the pain to appear and VAS pain score Walking time for pain improved in 3 patients VAS decreased in all patients 1 year [44]
7 Haleem et al., 2012 [42] 5 Case series Autogous BMSCs placed on platelet-rich fibrin glue RHSSK scores and MRI Improvement in RHSSK score and subjective symptoms MRI: complete defect fill and complete surface congruity with native cartilage 1 year [42]
8 Kasemkijwattana et al., 2011 [43] 2 Case report Autologous BMSCs (12 million) KOOS, IKDC score, and arthroscopy Improvements in KOOS and IKDC score Arthroscopy: Good defect fill, stiffness, and incorporation to the adjacent cartilage 30-31 months [43]
9 National University of Malaysia/ Cytopeutics (Malaysia) 50 Randomized controlled Autologous BMSCs VAS, IKDC Subjective Knee Evaluation Form, and x-ray NA 1 year NCT01459640
10 Royan Institute (Tehran, Iran) 40 Randomized triple-blinded Autologous BMSCs WOMAC, VAS, and MRI NA 6 months NCT01504464
11 Red de Terapia Celular (Barcelona, Spain) 12 Non- randomized open-label Autologous BMSCs (40 million) VAS, Oswestry disability index, and SF-36 life quality NA 2 years NCT01183728
12 Royan Institute 6 Non-randomized open-label BMSCs WOMAC, VAS, SF-36, and MRI NA 1 year NCT01207661
13 Royan Institute 6 Non-randomized open-label Autologous BMSCs VAS, WOMAC, x-ray, and MRI NA 6 months NCT01436058
14 Royan Institute 6 Non-randomized open-label Autologous BMSCs VAS, WOMAC, Harris Hip Score questionnaire, x- ray, and MRI NA 6 months NCT01500811
15 Stempeutics Research (Bangalore, India) 60 Randomized double-blind Allogeneic BMSCs (25, 50, 75, and 150 million) VAS, WOMAC, ICOAP, x-ray, and MRI NA 2 years NCT01453738
16 University of Marseille (Marseille, France) 50 Open-label Autologous BMSCs IKS and ICRS NA 1 year NCT01159899
17 Stempeutics Research Malaysia Sdn. Bhd (Malaysia) 72 Randomized double-blind Allogeneic BMSCs (25 and 50 million) VAS, WOMAC, ICOAP, x-ray, and MRI NA 2 years NCT01448434
18 Cairo University (Egypt) 25 Open-label Autologous BMSCs Clinical scoring, x-ray, and MRI NA 1 year NCT00891501
19 Royan Institute 6 Open-label Autologous BMSCs Pain, knee cartilage defects NA 1 year NCT00850187
20 Banc de Sang i Teixits (Barcelona, Spain) 15 Open-label Autologous BMSCs (40 million) VAS, HAQ, SF-36, and MRI NA 1 year NCT01227694
21 Mesoblast (Melbourne, Australia) 24 Randomized double-blind MSB-CAR001 VAS, KOOS, SF-36, x-ray, and MRI NA 2 years NCT01088191
  1. BM-MSC, bone marrow-derived mesenchymal stem cell; BMSC, bone marrow stromal cell; HAQ, Health Assessment Questionnaire; HPE, histopathological evaluation; ICOAP, Intermittent and Constant Osteoarthritis Pain; ICRS, International Cartilage Repair Society; IKDC, International Knee Documentation Committee; IKS, International Knee Score; IRB, institutional review board; KOOS, Knee and Osteoarthritis Outcome Score; MRI, magnetic resonance imaging; NA, not applicable; RHSSK, Lysholm and Revised Hospital for Special Surgery Knee; SF-36, Short Form Health Survey-36; VAS, Visual Analogue Scale; WOMAC, Western Ontario and McMaster Universities (Osteoarthritis Index).