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Table 1 Clinical trials using stem cells for treatment for critical limb ischemia registered under http://www.clinicaltrials.gov registry [6]

From: Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia

Trial number

Phase

Study period

Duration of follow-up

Route

Treatment

NCT00883870

1 and 2

April 2009 to Dec. 2011

6 months

IM

Ex vivo-cultured adult allogeneic MSCs versus plasmalyte A

NCT00616980

1 and 2

Dec. 2007 to Aug. 2010

6 months

IM

Autologous CD34+ cells

NCT00919958

1

June 2009 to June 2010

3 months

IM

Allogeneic PLX-PAD

NCT00951210

1

Aug. 2009 to Oct. 2011

3 months

IM

Allogeneic PLX-PAD

NCT01049919

1 and 2

June 2010 to May 2014

52 weeks

IM

Autologous concentrated BM aspirate using MarroStim PAD kit

NCT00468000

2

April 2007 to March 2011

12 months

IM

Autologous BM cells

NCT00987363

1 and 2

July 2009 to Dec. 2011

12 months

IA

Autologous BM-MNCs in DM

NCT01019681

1

Nov. 2009 to Nov. 2015

24 months

IM

Umbilical cord blood stem cells

NCT00872326

1 and 2

Dec. 2007 to May 2009

3 months

IA

Autologous BM-MNCs

NCT00523731

1

Jan. 2006 to March 2007

3 months

IM

Autologous, non-mobilized angiogenic cell precursor

NCT00392509

1 and 2

Oct. 2006 to Dec. 2008

6 months

IM

Aldehyde dehydrogenase bright stem and progenitor Cell

NCT01079403

1 and 2

Dec. 2009 to Dec. 2011

12 months

IA

Autologous adipose tissue-derived MSCs

NCT00498069

1 and 2

Nov. 2007 to Jan. 2014

5 years

IM

Autologous BM aspirate

NCT00922389

1 and 2

July 2009 to Jan. 2011

12 months

IM

G-CSF + PB MNCs

NCT00913900

1

May 2009 to Sept. 2012

6 months

IM

Autologous CD133+ cells

NCT00371371

1 and 2

Sept. 2006 to July 2013

6 months

IA

Autologous BM-MNCs

NCT00721006

2

Sept. 2006 to Dec. 2010

4 months

SC (40×)

Combination of stem cell therapy

NCT01065337

2

Oct. 2004 to Feb. 2009

12 months

IM/IA

Autologous BM-MNCs versus tissue repair cell CD90+ cells

NCT00533104

1 and 2

Oct. 2004 to Feb. 2009

6 months

IM (30×)

Autologous PB-MNCs and BM-MNCs

NCT00595257

1 and 2

Dec. 2007 to Aug. 2010

60 days

IM

Autologous BM aspirate using SmartPREP2 BMACs

NCT00434616

2 and 3

April 2007 to July 2011

3 months

IM

Autologous BM cell concentrate

NCT00904501

3

March 2009 to June 2014

6 months

IM

Autologous BM-MNCs

NCT00488020

1

April 2006 to June 2007

6 months

IM (40×)

Autologous BM-MNCs

NCT00518401

1

June 2007 to Oct. 2009

6 months

IM (40×)

Combination of stem cell mixture

NCT00221143

1 and 2

Nov. 2003 to Jan. 2008

12 weeks

IM (40×)

Autologous PB CD34 cells

NCT00539266

2 and 3

Oct. 2007 to Oct. 2010

1 year

IM

Autologous BM-MNCs (DM versus non-DM)

NCT00145262

2

Started in Aug. 2003

24 weeks

IM

Autologous BM-MNCs

NCT00282646

1 and 2

Oct. 2005 to March 2011

6 months

IA

Autologous BM-MNCs

  1. BM, bone marrow; BMAC, bone marrow aspirate concentrate; BM-MNC, bone marrow mononuclear cell; DM, diabetes mellitus; G-CSF, granulocyte colony-stimulating factor; IA, intra-arterial; IM, intramuscular; MSC, mesenchymal stem cell; PAD, peripheral arterial disease; PB, peripheral blood; PB-MNC, peripheral blood mononuclear cell; PLX-PAD, placental derived mesenchymal stem cells; SC, subcutaneous.