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Table 1 Clinical trials using stem cells for treatment for critical limb ischemia registered under http://www.clinicaltrials.gov registry [6]

From: Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia

Trial number Phase Study period Duration of follow-up Route Treatment
NCT00883870 1 and 2 April 2009 to Dec. 2011 6 months IM Ex vivo-cultured adult allogeneic MSCs versus plasmalyte A
NCT00616980 1 and 2 Dec. 2007 to Aug. 2010 6 months IM Autologous CD34+ cells
NCT00919958 1 June 2009 to June 2010 3 months IM Allogeneic PLX-PAD
NCT00951210 1 Aug. 2009 to Oct. 2011 3 months IM Allogeneic PLX-PAD
NCT01049919 1 and 2 June 2010 to May 2014 52 weeks IM Autologous concentrated BM aspirate using MarroStim PAD kit
NCT00468000 2 April 2007 to March 2011 12 months IM Autologous BM cells
NCT00987363 1 and 2 July 2009 to Dec. 2011 12 months IA Autologous BM-MNCs in DM
NCT01019681 1 Nov. 2009 to Nov. 2015 24 months IM Umbilical cord blood stem cells
NCT00872326 1 and 2 Dec. 2007 to May 2009 3 months IA Autologous BM-MNCs
NCT00523731 1 Jan. 2006 to March 2007 3 months IM Autologous, non-mobilized angiogenic cell precursor
NCT00392509 1 and 2 Oct. 2006 to Dec. 2008 6 months IM Aldehyde dehydrogenase bright stem and progenitor Cell
NCT01079403 1 and 2 Dec. 2009 to Dec. 2011 12 months IA Autologous adipose tissue-derived MSCs
NCT00498069 1 and 2 Nov. 2007 to Jan. 2014 5 years IM Autologous BM aspirate
NCT00922389 1 and 2 July 2009 to Jan. 2011 12 months IM G-CSF + PB MNCs
NCT00913900 1 May 2009 to Sept. 2012 6 months IM Autologous CD133+ cells
NCT00371371 1 and 2 Sept. 2006 to July 2013 6 months IA Autologous BM-MNCs
NCT00721006 2 Sept. 2006 to Dec. 2010 4 months SC (40×) Combination of stem cell therapy
NCT01065337 2 Oct. 2004 to Feb. 2009 12 months IM/IA Autologous BM-MNCs versus tissue repair cell CD90+ cells
NCT00533104 1 and 2 Oct. 2004 to Feb. 2009 6 months IM (30×) Autologous PB-MNCs and BM-MNCs
NCT00595257 1 and 2 Dec. 2007 to Aug. 2010 60 days IM Autologous BM aspirate using SmartPREP2 BMACs
NCT00434616 2 and 3 April 2007 to July 2011 3 months IM Autologous BM cell concentrate
NCT00904501 3 March 2009 to June 2014 6 months IM Autologous BM-MNCs
NCT00488020 1 April 2006 to June 2007 6 months IM (40×) Autologous BM-MNCs
NCT00518401 1 June 2007 to Oct. 2009 6 months IM (40×) Combination of stem cell mixture
NCT00221143 1 and 2 Nov. 2003 to Jan. 2008 12 weeks IM (40×) Autologous PB CD34 cells
NCT00539266 2 and 3 Oct. 2007 to Oct. 2010 1 year IM Autologous BM-MNCs (DM versus non-DM)
NCT00145262 2 Started in Aug. 2003 24 weeks IM Autologous BM-MNCs
NCT00282646 1 and 2 Oct. 2005 to March 2011 6 months IA Autologous BM-MNCs
  1. BM, bone marrow; BMAC, bone marrow aspirate concentrate; BM-MNC, bone marrow mononuclear cell; DM, diabetes mellitus; G-CSF, granulocyte colony-stimulating factor; IA, intra-arterial; IM, intramuscular; MSC, mesenchymal stem cell; PAD, peripheral arterial disease; PB, peripheral blood; PB-MNC, peripheral blood mononuclear cell; PLX-PAD, placental derived mesenchymal stem cells; SC, subcutaneous.