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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Genetic background affects induced pluripotent stem cell generation

Figure 4

Pluripotency of induced pluripotent stem cells (iPSCs) derived from mouse embryonic fibroblast (MEFs) of each strain. Doxycycline-independent cell lines from all the strains were capable of producing teratomas in NOD SCID mice by 5 weeks post-injection as shown in these histologic images, all of which are stained with hematoxylin and eosin and viewed at 200× magnification. (A) NON/LtJ; (B) C57BL/6J; (C) BA/2J; (D) BALB/cJ; (E) 129S1/SvlmJ; (F) CAST/EiJ. Tissues from all three germ layers were identified on each section as indicated by the labels: Ect, ectoderm; Mes, mesoderm; End, endoderm.

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