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Figure 3 | Stem Cell Research & Therapy

Figure 3

From: Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice

Figure 3

Inhibition of neuroinflammation in 6-OHDA PD mouse model activates SVZ neuroblast generation and migration. (A) Confocal TILE scans of midbrain sagittal sections after the indicated treatments, showing the degeneration of TH+ neurons in the SN (arrows) and projections to the striatum (asterisk). (B) Maximum intensity projections of the pRMS from indicated treatment groups; dotted lines indicate ventricle surface; quantification in (C); *P ≤0.05 Mann-Whitney-U-Test, error bars s.e.m. (D) Confocal TILE scans from indicated treatment groups showing Dcx+ neuroblasts in the SVZ, pRMS and striatum. Positions of Dcx+ neuroblasts and the lining of the anterior ventricular wall were determined in Cartesian coordinates and categorized according to the shortest vector length. (E) Quantification of D with sorting of Dcx+ cells into indicated groups of migration distances; *P ≤0.05 Mann-Whitney-U-Test, error bars s.e.m., number of animals: sham n = 6; sham + Minocycline n = 6; 6-OHDA n = 4; 6-OHDA + Minocycline n = 3.

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