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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice

Figure 4

Long-term anti-inflammatory treatment of 6-OHDA PD mice leads to functional regeneration via oligodendrogenesis. (A) Timeline showing the experimental setup. (B) Quantification of Rota-Meter test showing reduction of turning behavior after Minocycline treatment; *P ≤0.05 Mann-Whitney-U-Test, error bars s.e.m., n = 4 animals. (C) Bright field image of mouse brain sagittal section; red dotted line indicates region analyzed for EdU+/GST-π+ cells. (D) Mean number of EdU+ cells per brain section in striatal region indicated in C; *P ≤0.05 one-tailed t-test, error bars s.e.m., number of animals: lesion n = 5, lesion + Minocycline n = 6. (E) Confocal image showing GST-π+/EdU+ cells in the striatum (region indicated in C). (F) Quantification of GST-π+/EdU+ cells in the striatum; mean per section; *P ≤0.05 one-tailed t-test, error bars s.e.m., number of animals: lesion n = 5, lesion + Minocycline n = 6 animals.

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