Figure 2
From: Cancerous stem cells: deviant stem cells with cancer-causing misbehavior
Model for colon cancer initiated by stem cells. Colon stem cells are located at the base of the crypt in normal colon and will differentiate while moving up the crypt in about 5 days. Adenoma will develop upon deregulation of stem cell homeostasis. Upon further neoplastic injuries, stem cells will transform into cancerous stem cells (CSCs) with some limited ability to differentiate.