The gene expression and DNA methylation profiles of fibroblasts and iPSCs. (A) A dendrogram generated based on the unsupervised hierarchical clustering analysis of gene expression data from childhood cerebral adrenoleukodystrophy (CCALD) patient and control fibroblasts and induced pluripotent stem cells (iPSCs) is provided. The analysis was based on data from 672 probe sets producing log2-tranformed gene expression scores with coefficient of variation (CV) > 0.25 and conducted using average linkage and Euclidean distance; (B) A dendrogram generated based on the unsupervised hierarchical clustering analysis of DNA methylation data from CCALD patient and control fibroblasts and iPSCs is provided. Data from 7,493 DNA methylation assays interrogating autosomal CpG loci with CV > 0.5 and the fifth largest and smallest β-values being > 0.6 and < 0.4, respectively, were used in this analysis in order to represent the most variable loci. Clustering was performed using average linkage and the Pearson dissimilarity distance.