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Table 2 Expression of extracellular matrix and adhesion molecules in LSK populations across different microenvironments and stages of development

From: Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development

Gene FL14.5 FL17.5 FBM17.7 Adult BM
Transmembrane molecules
Cd44 0.15 0.24 0.47 1
Entpd1 0.03 0.12 0.32 1
Itga4 0.38 0.49 0.62 1
Itgal 0.63 0.8 1.23 1
Itgam 0.3 0.43 0.72 1
Itgav 0.27 0.32 0.54 1
Itgb1 0.57 0.46 0.68 1
Itgb2 0.2 0.35 0.61 1
Itgb3 1.28 0.54 0.58 1
Pecam1 0.2 0.56 0.82 1
Sell 0.06 0.12 0.53 1
Selp 0.13 0.2 0.62 1
Sgce 0.1 0.39 0.68 1
Cell-cell adhesion molecules
Vcam1 0.08 0.27 0.36 1
Other adhesion molecules
Ctnna1 0.17 0.36 0.56 1
Ctnnb1 0.56 0.39 0.97 1
Emilin1 0.62 0.86 0.82 1
Lamb2 0.06 0.11 0.36 1
Lamc1 0.57 0.43 0.68 1
Collagens and extracellular matrix structural constituents
Col4a1 0.07 0.25 0.74 1
Col4a2 0.11 0.46 0.68 1
Extracellular matrix proteases
Adamts5 0.03 0.1 0.61 1
Mmp2 0.12 0.26 0.58 1
Extracellular matrix proteases
Timp2 0.08 0.22 0.58 1
Other extracellular matrix molecules
Ecm1 0.33 0.55 0.56 1
Tgfbi 0.07 0.22 0.45 1
Thbs1 4.26 1.02 0.43 1
Housekeeping gene
Hprt1 0.13 0.18 0.44 1
  1. Table demonstrates fold change values for samples in which gene expression was detected at all the points of study, compared to gene expression in adult bone marrow. Adult BM, four-week old adult bone marrow; FBM17.5, fetal bone marrow at Day 17.5 of gestation; FL14.5, fetal liver at Day 14.5 of gestation; FL17.5, fetal liver at Day 17.5 of gestation; LSK, Lineage- Sca-1+ c-Kit+.