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Table 1 Zebrafish mutant strains relevant to human erythropoiesis-related diseases

From: Zebrafish erythropoiesis and the utility of fish as models of anemia

Human disease Mutant Gene Function Reference
Erythropoietic protoporphyria dracula Ferrochelatase Enzyme functioning in heme synthesis [50]
Hemolytic anemia merlot Erythrocyte membrane protein 4.1R Structural protein of erythrocyte membrane
Stabilizes β-spectrin/actin interaction
[54]
Congenital dyserythropoietic anemia type II (HEMPAS) retsina Solute carrier family 4 (anion exchanger 1a or band 3) Chloride exchanger [56]
Hereditary spherocytosis riesling β-spectrin Structural protein of erythrocyte membrane [59]
Congenital sideroblastic anemia sauternes Aminolevulinate synthetase 2 (alas2) Enzyme functioning in heme synthesis [63]
Hypochromic anemia
(resembles thalassemia)
zinfandel Globin Oxygen transport [35]
Type IV hemochromatosis weissherbst Ferroportin 1 Iron transport [65]
  1. HEMPAS, hereditary erythroblastic multinuclearity with positive acidified serum lysis test.