Zebrafish erythropoiesis and the utility of fish as models of anemia

Table 1 Zebrafish mutant strains relevant to human erythropoiesis-related diseases

Human disease	Mutant	Gene	Function	Reference
Erythropoietic protoporphyria	dracula	Ferrochelatase	Enzyme functioning in heme synthesis	[50]
Hemolytic anemia	merlot	Erythrocyte membrane protein 4.1R	Structural protein of erythrocyte membrane Stabilizes β-spectrin/actin interaction	[54]
Congenital dyserythropoietic anemia type II (HEMPAS)	retsina	Solute carrier family 4 (anion exchanger 1a or band 3)	Chloride exchanger	[56]
Hereditary spherocytosis	riesling	β-spectrin	Structural protein of erythrocyte membrane	[59]
Congenital sideroblastic anemia	sauternes	Aminolevulinate synthetase 2 (alas2)	Enzyme functioning in heme synthesis	[63]
Hypochromic anemia (resembles thalassemia)	zinfandel	Globin	Oxygen transport	[35]
Type IV hemochromatosis	weissherbst	Ferroportin 1	Iron transport	[65]

HEMPAS, hereditary erythroblastic multinuclearity with positive acidified serum lysis test.

ISSN: 1757-6512