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Figure 8 | Stem Cell Research & Therapy

Figure 8

From: Umbilical cord blood-derived mesenchymal stem cells consist of a unique population of progenitors co-expressing mesenchymal stem cell and neuronal markers capable of instantaneous neuronal differentiation

Figure 8

Schematic showing the heterogeneity of mesenchymal population obtained from human umbilical cord blood. Human umbilical cord blood-derived mononuclear cells (hUCB-MNCs) consist of a heterogeneous pluripotent population of cells with varying neurogenic potential. Upon expansion, the number of cells with inherent neurogenic potential may increase in some cases, which generates more neuronal differentiation instantaneously, while in other cases cells with less neurogenic potential are expanded, which requires extensive treatment with a combination of multiple growth factors to achieve neuronal differentiation. aFGF, acidic fibroblast growth factor; bFGF, basic fibroblast growth factor; ╬▓ME, beta-mercaptoethanol; IBMX, 3-isobutyl-1-methylxanthine; IMDM, Iscove's modified Dulbecco's medium; MSC, mesenchymal stem cell; NGF, nerve growth factor; PMA, phorbol myristate acetate; RA, retinoic acid.

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