| | |
EGF
|
FGF-b
|
HGF
|
IGF-1
|
PDGF-AB
|
TGF-b
|
VEGF
|
SDF-1a
|
IL-1a
|
IL-1b
|
|---|
|
Picograms per 1 mg protein, mean ± SEM
|
PGCAP
|
289.87 ± 50.14
|
5.36 ± 0.62
|
21.24 ± 2.73
|
609.61 ± 81.92
|
7,249.57 ± 1,305.81
|
2,166.77 ± 248.38
|
99.55 ± 26
|
142.88 ± 7.87
|
0.07 ± 0.01
|
2.60 ± 0.99
|
| |
PPP
|
79.36 ± 7.93
|
1.76 ± 0.16
|
12.19 ± 1.1
|
3,310.22 ± 362.1
|
2,146.71 ± 237.89
|
15.66 ± 1.81
|
16.50 ± 2.08
|
25.10 ± 2.34
|
0.19 ± 0.03
|
0.35 ± 0.20
|
| |
PL
|
44.48 ± 2.09
|
2.22 ± 0.91
|
18.76 ± 1.76
|
2,622.15 ± 279.86
|
705.42 ± 84.94
|
1,180.52 ± 37.61
|
17.09 ± 3.08
|
36.67 ± 5.46
|
0.10 ± 0.02
|
0.23 ± 0.05
|
| |
TC
|
N.D.
|
0.04
|
0.07
|
16.62
|
0.03
|
42.91
|
0.13
|
65.22
|
0.23
|
0.30
|
| |
FCS
|
N.D.
|
0.11
|
N.D.
|
1,916.29 ± 27.95
|
N.D.
|
100.03
|
N.D.
|
37.60 ± 1.22
|
0.57 ± 0.32
|
0.07
|
|
Picograms for 100 μL of products
|
PGCAP
|
2,683.15 ± 325.20
|
50.26 ± 6.45
|
189.57 ± 19.91
|
5,341.28 ± 395.90
|
63,806.01 ± 5,642.06
|
21,407.23 ± 2,732.49
|
962.80 ± 83.56
|
926.25 ± 84.40
|
0.41 ± 0.08
|
24.89 ± 12.83
|
| |
TC
|
n.d.
|
0.50
|
0.84
|
191.08
|
0.31
|
493.50
|
1.50
|
150.00
|
0.53
|
0.68
|
|
Ratio
|
PGCAP/ PPP
|
3.65a
|
3.04b
|
1.74c
|
0.18 N.S.
|
3.38d
|
138.36a
|
6.03a
|
5.69b
|
0.38 N.S.
|
7.37c
|
| |
PGCAP/ PL
|
6.52a
|
2.41b
|
1.13 N.S.
|
0.23 N.S.
|
10.28d
|
1.84a
|
5.83a
|
3.9b
|
0.71 N.S.
|
11.23 N.S.
|
| |
PGACP/TC
|
N.D.
|
123.31c
|
292.51 N.S.
|
36.68 N.D.
|
269,806.08a
|
50.49d
|
763.24a
|
2.19a
|
0.31 N.S.
|
8.77 N.S.
|
| |
PGCAP/FCS
|
N.D.
|
50.93c
|
N.D.
|
0.32c
|
N.D.
|
21.66d
|
N.D.
|
3.8a
|
0.12c
|
36.24 N.S.
|
| |
PPP/PGCAP
|
0.27 N.S.
|
0.33 N.S.
|
0.57 N.S.
|
5.43d
|
0.3 N.S.
|
0.01 N.S.
|
0.17 N.S.
|
0.17 N.S.
|
2.62 N.S.
|
0.14 N.S.
|
| |
PL/PGCAP
|
0.15 N.S.
|
0.41 N.S.
|
0.88 N.S.
|
4.3d
|
0.1 N.S.
|
0.54 N.S.
|
0.17 N.S.
|
0.26 N.S.
|
1.41 N.S.
|
0.09 N.S.
|
- Analysis-of-variance test followed by Student Newman-Keuls test. aP <0.001, bP <0.01, cP <0.05, dP <0.0001. EGF, epidermal growth factor; FCS, fetal calf serum; FGF-b, fibroblast growth factor-beta; HGF, hepatocyte growth factor; IGF-1, insulin-like growth factor-1; IL, interleukin; N.D., not determined; N.S., not significant; PDGF-AB, platelet-derived growth factor-AB; PGCAP, platelet glue obtained from cryoprecipitation of apheresis platelet products; PL, platelet lysate; PPP, platelet-poor plasma; SDF-1a, stromal cell-derived factor 1 alpha; SEM, standard error of the mean; TC, Tissucol; TGF-b, transforming growth factor-beta; VEGF, vascular endothelial growth factor.
