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Table 2 Some skeletal myogenesis-related genes are downregulated in MDSCs by myostatin genetic inactivation, whereas others remain unchanged

From: Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle

Gene Function WT KO
Spp1 Secreted phosphoprotein 1 (osteopontin) 70.8 20.3
Actc 1 α-Actin (cardiac) 39.9 6.5
Myo D1 Myogenic differentiation 1 17.5 2.7
Cadherin 15 Cadherin 15 8.7 1.7
Myf 5 Myogenic factor 5 4.2 2.7
Notch 2 Notch gene homolog 2 4.2 2.8
BMPR 2 Bone morphogenetic receptor 2 23.3 20.3
BMPR 1a Bone morphogenetic receptor 1a 8.1 10.4
BMPR 1b Bone morphogenetic receptor 1b 0.8 0.8
BMPR 4 Bone morphogenetic protein 4 2.7 2.7
IGF 1 Insulin-like growth factor 1 5.1 4.2
Jag 1 Jagged 1 2.8 3.4
Fzd 1 Frizzled homolog 1 2.7 2.8
Notch 1 Notch gene homolog 1 2.6 2.7
Notch 3 Notch gene homolog 3 2.8 2.6
  1. RNA from the two MDSC types at 80% confluence (not undergoing myogenesis) were treated with DNAse and submitted to DNA microarrays. Some key myogenesis-related genes are selected. Values are relative expression levels normalized by housekeeping genes. GAPDH expression was 98 to 102. MDSC, muscle-derived stem cell; WT, wild type; KO, myostatin knockout.