Figure 4

Expression of brain repair markers in the peri-infarct area at 14 d after acute intravenous (i.v.) administration of allogenic bone marrow-derived mesenchymal (BM-MSC) and adipose tissue-derived mesenchymal (AD-MSC) cells in the permanent middle cerebral artery occlusion (pMCAO) model. (A) Confocal images showing the levels of vascular epithelial growth factor (VEGF), neuronal nuclei (NeuN), synaptophysin (SYP), glial fiibrillary acid protein (GFAP), oligodendrocyte (OLIG2), brain-derived neurotrophic factor (BDNF) and neurofilament (NF) at 14 d in the infarct area after BM-MSC and AD-MSC administration (scale bars = 20 μm). (B) Western blot analysis showing that levels of VEGF, SYP, OLIG2, NF and BDNF were augmented at 14 d after BM-MSC and AD-MSC administration. The levels of GFAP were decreased in both groups. There were no significant differences in the results with respect to the cell source. Data are shown as mean ± SD (n = 3);*P < 0.05.