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Figure 5 | Stem Cell Research & Therapy

Figure 5

From: Comparison of the therapeutic effects of human and mouse adipose-derived stem cells in a murine model of lipopolysaccharide-induced acute lung injury

Figure 5

The effects of hASC and mASCs on inflammatory cytokine levels in the lung. Protein levels of various proinflammatory cytokines and chemokines 24 hours after PBS or LPS challenge were quantified for lung lysates using a multiplex immunoassay. All levels were normalized to total lung lysate protein concentration. Protein levels of (a) macrophage inflammatory protein 2 (MIP-2), (b) interleukin 1 alpha (IL-1α), (c) IL-1β, (d) interferon gamma (IFN-γ), (e) granulocyte macrophage colony-stimulating factor (GM-CSF), and (f) IL-10 are shown for PBS-or LPS-challenged mice injected with HBSS, hASCs, or mASCs. N = 4, 4, 5, 4, and 5 for PBS + hASC, PBS + mASC, LPS + HBSS, LPS + hASC, and LPS + mASC, respectively. Significance was defined as ** for P <0.01 compared to HBSS-treated LPS-challenged mice levels. hASCs, human adipose-derived stem cells; HBSS, Hank's balanced salt solution; LPS, lipopolysaccharide; mASCs, mouse adipose-derived stem cells; PBS, phosphate-buffered saline.

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