Skip to main content
Figure 2 | Stem Cell Research & Therapy

Figure 2

From: BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells

Figure 2

Overview of molecular signaling pathway and quantitative real-time polymerase chain reaction analysis of nuclear factor-kappa-B (NF-κB). (a) Dotted line represents the molecular pathway that BX795 inhibits, specifically at IKKε. The pathway with non-dotted lines represents the additional pathways that BAY11 inhibits, including the IKKβ and IRF7 pathways. (b) Relative NF-κB levels with and without BAY11. Overall levels decrease in the presence of BAY11, contributing to the increase in OCT4 expression previously seen. Asterisks indicate statistically significant changes in expression where P value was less than 0.05. BAY11, BAY 11-7082; IFNAR, interferon-α/β receptor; IKK, IκB kinase; IRAK1, interleukin-1R-associated kinase 1; IRF, interferon regulatory factor; ; ISRE, interferon stimulated response element; MDA5, melanoma differentiation-associated gene 5; MYD88, myeloid differentiation primary-response gene 88; RIG-I, retinoic acid-inducible gene I; STAT1/2, signal transducer and activator of transcription 1/2; TLR7/8; TRAF6, tumor necrosis factor receptor-associated factor 6.

Back to article page