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Table 1 Comparison of bone marrow-derived stem cells and adipose-derived stem cells as ALI/ARDS therapeutics

From: Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury

Isolation of cells Safe, relatively non-invasive and inexpensive procedure. Adipose tissue is abundant, expendable, easily accessible, and can be a waste product of many therapeutic and cosmetic procedures Painful, invasive, and relatively costly procedure
Cell yields High Generally low
Proliferation and differentiation High proliferation kinetics; expandable in culture for autologous transplantation Differentiation ability impaired with increasing age
Viral infection Adipose tissue does not have high exposure to viruses Bone marrow cells are susceptible to virus infection and replication, including hepatitis B and human immunodeficiency virus
Efficacy Few reports of efficacy in lung injury models to date; not yet tested in sepsis models Efficacy demonstrated in animal models of ALI and sepsis
Other ASCs promote the growth of tumor cells  
  1. ALI, acute lung injury; ARDS, acute respiratory distress syndrome; ASC, adipose-derived stem cell; BMSC, bone marrow-derived stem cell.