Table 1 Comparison of bone marrow-derived stem cells and adipose-derived stem cells as ALI/ARDS therapeutics
From: Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury
| Â | ASCs | BMSCs |
|---|---|---|
Isolation of cells | Safe, relatively non-invasive and inexpensive procedure. Adipose tissue is abundant, expendable, easily accessible, and can be a waste product of many therapeutic and cosmetic procedures | Painful, invasive, and relatively costly procedure |
Cell yields | High | Generally low |
Proliferation and differentiation | High proliferation kinetics; expandable in culture for autologous transplantation | Differentiation ability impaired with increasing age |
Viral infection | Adipose tissue does not have high exposure to viruses | Bone marrow cells are susceptible to virus infection and replication, including hepatitis B and human immunodeficiency virus |
Efficacy | Few reports of efficacy in lung injury models to date; not yet tested in sepsis models | Efficacy demonstrated in animal models of ALI and sepsis |
Other | ASCs promote the growth of tumor cells | Â |