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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Infusion of freshly isolated autologous bone marrow derived mononuclear cells prevents endotoxin-induced lung injury in an ex-vivo perfused swine model

Figure 1

Systemic administration of freshly isolated autologous whole bone marrow nuclear cells (BMC) modifies endotoxin (LPS) induced lung inflammation. A. Lung biopsies were obtained at the indicated time points after endotoxin and stained with an anti-myeloperoxidase (MPO) antibody to detect neutrophils. Samples from two independent animals treated with endotoxin (Endo1 and 2) are shown. Note the significant alteration of lung architecture with increased inflammatory infiltrates and edema at 15 and 45 minutes after endotoxin. B. Histological lung sections stained with MPO from swine preparations infused with total BMCs 15 minutes after endotoxin. Three independent animals are shown (BMC 1, 2 and 3). Tissue samples were collected at the indicated time points after endotoxin. Notice reduction in the severity of inflammation and edema compared to endotoxin alone treated swine. LPS, lipopolysaccharide.

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Stem Cell Research & Therapy

ISSN: 1757-6512