Table 1 Hepatic gene expression 30 minutes after endotoxemia normalized to control (no endotoxin).
Encoded protein | Fold Increase after LPS |
|---|---|
MHC class II | 62 |
Serine protease inhibitor | 19 |
MHC class I | 16 |
AMCF-1 | 14 |
Tumor necrosis factor (TNF) | 14 |
Prointerleukin-1 beta (IL1B) | 11 |
Lysozyme (LYZ) Hydroxymethylgluatryl-CoA | 6 |
Synthase (HMGCS2) | 5 |
T cell receptor alpha chain (TCR-a) | 5 |
Interleukin-6 (IL6) | 4 |
Interleukin-1alpha (IL1A) | 4 |
Chemokine ligand 2 (CXCL2) | 4 |
T cell receptor beta (TCR-b) | 4 |
20-beta-hydroxysteroid dehydrogenase (CBR1) | 3 |
C-JUN protein (C-JUN) | 3 |
MHC class II SLA-DRB-c | 3 |
Complement C7 (C7) | 3 |
Heparin binding protein 61 | 3 |
Glutathione S-transferase (GST) | 3 |
Prostaglandin G/H synthase-2 (PGHS-2) | 3 |
RANTES protein (RANTES) | 3 |
MIP-1 beta protein (MIP-1BETA) | 3 |
Antimicrobial protein hepcidin(HAMP) | 3 |
Interleukin-1 beta converting Enzyme (CASP1) | 3 |
Killer cell lectin-like receptor(KLRK1) | 3 |
CD45 antigen isoform 1 precursor (CD45) | 2 |
Endothelin (EDN) | 2 |
Macrophage inflammatory protein 1 alpha (CCL3) | 2 |
Tissue factor | 2 |
TcR gamma chain | 2 |
Plasminogen activator (PLAU) | 2 |
Complement C1qA (C1QA) | 2 |
Heat shock protein 70.2 (HSP70.2) | 2 |
Neuron-derived orphan receptor alpha (NOR-1) | 2 |
Chemokine C-C motifreceptor 5 (CCR5) | 2 |
Complement C1qB (C1QB) | 2 |
SLA-DQ beta1 domanin | 2 |
Beta-2 microglobulin (B2M) | 2 |
TACSTD1 | 2 |
CD8 antigen alpha polypeptide (CD8A) | 2 |
Transcription factor PU.1 (PU.1) | 2 |
NF-k gene enhancer inhibitor (NFKBIA) | 2 |