Figure 8
Femoral arterial vasorelaxation and nitric oxide (NO) release following D-galactose administration. Despite lack of a significant difference in vasoconstrictive response of femoral artery to phenylephrine (PE) between DPP4-deficient and Fischer 344 rats (A), remarkably reduced vasorelaxation of femoral artery to achetylcholine (ACH) noted in DPP4-deficient rats compared to that in WT Fischer rats (B). * vs. DPP4D, P < 0.01. C) Substantially reduced NO release from endothelium of femoral artery in DPP4-deficient rats compared to that in WT Fischer rats. * vs. DPP4D, P < 0.001 (n = 9 per group).