Schematic illustration of PEGMEMA
copolymer synthesis and cross-linking with thiol-modified hyaluronic acid. (A) Synthesis route via deactivation-enhanced atom transfer radical polymerisation (ATRP) at 60°C. (B) Cross-linking of PEGMEMA–MEO2MA–PEGDA and HA hybrid (P-SH-HA) polymer with thiol-modified hyaluronic acid via Michael-type addition reaction showing encapsulation of human adipose-derived stem cells (hADSCs) in the P-SH-HA hydrogel at 37°C. (C) Cartoon picture: application of P-SH-HA hydrogel on a skin wound. The hADSCs are embedded in situ with P-SH-HA hydrogel and applied on the wound, which secrete growth factors to accelerate wound healing. EGF, epidermal growth factor; FGF, fibroblast growth factor; PDGF, platelet-derived growth factor; TGF-β, transforming growth factor beta; VEGF, vascular endothelial growth factor.