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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells

Figure 2

Oxidative stress promotes endothelial gene expression in mesenchymal stem cells (MSCs). MSCs were treated with either H2O2 for 1 week (0 to 100 μM; A through C) or GOX for 48 hours (0 to 5 mU/ml; D through F). Expression of the endothelial markers Flt1 (A, D), vWF (B, E), and PECAM1 (C, F) was determined with qRT-PCR. Values are expressed as mean ± SEM after normalizing gene expression to GAPDH (A through C) or 18S (D through F) expression. For A through C, n ≥ 4, and D through F, n ≥ 6. *P < 0.05 and **P < 0.01 when compared with control (0 μM H2O2 or 0 mU/ml GOX) by one-way ANOVA followed by Dunnett posttest.

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