Figure 9

Oxidative stress regulates cardiogenic gene expression in cardiac progenitor cells. Cardiogenic gene expression in cardiac progenitor cells treated with GOX (0 or 5 mU/ml) was determined with qRT-PCR. An increase in expression of Notch1 (P < 0.001), Hes5 (P < 0.05), flt1 (P = 0.08), vWF (P < 0.05), nkx2-5 (P < 0.01), and sm22α (P < 0.05) was observed. Values are expressed as mean ± SEM after normalizing gene expression to 18S expression: n = 3, *P < 0.05, **P < 0.01, ***P < 0.001 compared with control (0 mU/ml GOX) with the Student unpaired t test.