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Table 1 Differentially expressed human embryonic stem cell–endothelial cell day 2 transcription factor-encoding genes

From: Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment

Gene symbol

Entrez gene name

Fold change

FDR

Bivalency score

ANKRA2

Ankyrin repeat, family A (RFXANK-like), 2

−1.64

0.01

0

ASCL2

Achaete-scute complex homolog 2 (Drosophila)

1.24

0.05

5

CXXC1

CXXC finger protein 1

1.82

0.02

0

DNMT3L

DNA (cytosine-5)-methyltransferase 3-like

1.29

0.01

0

EHMT2

Euchromatic histone-lysine N-methyltransferase 2

1.46

0.02

0

FOXA2

Forkhead box A2

1.51

<0.005

5

GABPB1

GA binding protein transcription factor, beta subunit 1

−1.47

0.02

0

HDAC5

Histone deacetylase 5

1.21

0.03

0

L3MBTL2

l(3)mbt-like 2 (Drosophila)

1.37

0.03

0

MLL3

Myeloid/lymphoid or mixed-lineage leukemia 3

1.28

0.01

0

MNT

MAX binding protein

1.50

0.02

0

RAX2 (human)

Retina and anterior neural fold homeobox 2

1.57

0.04

0

RBM14

RNA binding motif protein 14

1.72

0.01

0

RFX1 (includes EG:100038773)

Regulatory factor X, 1 (influences HLA class II expression)

1.47

0.02

0

SNAPC4

Small nuclear RNA activating complex, polypeptide 4, 190 kDa

1.80

0.04

0

SRA1

Steroid receptor RNA activator 1

1.34

0.01

0

TAF6L

TAF6-like RNA polymerase II, p300/CBP-associated factor-associated factor, 65 kDa

1.75

0.01

0

TFAP4

Transcription factor AP-4 (activating enhancer binding protein 4)

1.62

0.01

0

TSC22D3

TSC22 domain family, member 3

−1.73

<0.005

5

UBTF

Upstream binding transcription factor, RNA polymerase I

1.60

0.02

0

USF2

Upstream transcription factor 2, c-fos interacting

1.73

0.04

0

ZNF35

Zinc finger protein 35

1.33

0.02

0

  1. Fold change and false discovery rate (FDR) for the 22 differentially expressed genes are shown. In silico prediction of bivalency involved assigning bivalency scores from 0 to 5: 0, not bivalently marked; 5, genes are robustly bivalent with enriched domains of H3K4me3 and H3K27me3 within 2 kb of their transcription start site.