MSC delivery route | Lung injury model | Mechanism of therapy | Reference |
---|---|---|---|
IV delivery immediately post-injury | Murine IT bleomycin-induced ALI | Engrafted male cells were localized to areas of bleomycin-induced injury and exhibited an epithelium-like morphology | [28] |
Reduced the degree of bleomycin-induced inflammation and collagen deposition within lung tissue | |||
IV delivery 6 h post-injury | Murine IT bleomycin-induced ALI | Differentiation of engrafted BMDMSC into specific and distinct lung cell phenotypes | [29] |
An increase in circulating levels of G-CSF and GM-CSF and with a decrease in inflammatory cytokines | |||
IT delivery 4 h and 24 h post-injury | Murine IT LPS-induced ALI | Significant decrease in excess lung water, pulmonary edema, bronchoalveolar lavage protein, endothelial and alveolar epithelial permeability | [35] |
IT delivery 1 h and 24 h post-injury | Endotoxin-induced ALI in ex vivo perfused human lung | Secretion of KGF by mesenchymal stem cells resulting in improved endothelial permeability and restoration of alveolar epithelium fluid transport | [36] |
IV delivery immediately post-injury | Murine IT bleomycin-induced ALI | Secretion of IL-1 receptor antagonist | [37] |
Inhibition of TNF-α production by macrophage and IL-1a-dependent T cell line | |||
IV delivery 1 h and 24 h post-injury | Murine IP LPS-induced ALI | Prevented endotoxin-induced lung inflammation, injury, and edema | [39] |
Suppressed the endotoxin-induced increase in circulating pro-inflammatory cytokines without decreasing circulating levels of anti-inflammatory mediators | |||
IV delivery immediately post-injury | Murine IT bleomycin-induced ALI | Promoted Th1 phenotype and inhibited Th2-mediated allergic airways inflammation | [44] |
IT delivery 4 h post-injury | Murine IT LPS-induced ALI | Diminished levels of alveolar CD4 + CD25 + Foxp3 + Treg and balancing anti- and pro-inflammatory factors | [46] |
IV delivery 6 h and 24 h post-injury | Murine CLP-induced ALI | Modification of inflammatory gene transcriptional activity | [48] |
Downregulation of the acute inflammatory response and upregulation of pathways relevant to phagocytosis and bacterial clearance | |||
IT delivery 4 h and 24 h post-injury | E. coli pneumonia-induced ALI | Secretion of the anti-microbial peptide LL-37 resulting in increased bacterial clearance | [49] |