Figure 1
From: Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging
Representative micrographs depicting morphological change after 21 days of exposure to differentiation media. Representative micrographs show anti-FABP4, anti-osteocalcin, anti-aggrecan and anti-cardiac myosin heavy chain staining in differentiating bone marrow-derived mesenchymal stem cells (BM-MSCs). BM-MSCs derived from aged rats fail to undergo adipogenic, chondrogenic, osteogenic and cardiomyogenic differentiation. BM-MSCs derived from young rats transform into fat-forming adipocytes, cartilage-forming chondrocytes, bone-forming osteocytes and cardiomyogenic cells. BM-MSCs were isolated from ‘aged’ and ‘young’ Sprague Dawley rats (15 months and 4 months).