Skip to main content
Figure 1 | Stem Cell Research & Therapy

Figure 1

From: CD70–CD27 ligation between neural stem cells and CD4+ T cells induces Fas–FasL-mediated T-cell death

Figure 1

Human neural stem cells (HB1.F3) induce T-cell apoptosis. (A) The morphology of CD4+ T cells after the co-culture with HB1.F3 was characteristic of apoptotic cells: blebbing and shrinkage of cytoplasm (scale bar: 20 μm). (B) CD4+ T cells showed maximal apoptosis at 24 hrs (■, AV+/PI- and AV+/PI+ cells), however the total dead cells of T cells increased by time dependent manner (, total of AV+/PI-, AV+/PI+, and AV-/PI+ cells). (C) The degree of CD4+ T-cell apoptosis occurred in an HB1.F3 density-dependent manner. (D) Contrary to CD4+ T-cell apoptosis by pNSCs or HB1.F3, the apoptosis levels of CD4+ T cells by HEK-293, Detroit 551, and human umbilical cord blood-derived mesenchymal stem cells did not significantly differ from each other. MSC, mesenchymal stem cell; NSC, neural stem cell.

Back to article page