|
Variable
|
Group 1
|
Group 2
|
Group 3
|
Group 4
|
Group 5
|
P value
|
|---|
|
At 0 hours
| | | | | | |
|
Serum creatinine (mg/dl)
|
0.21 ± 0.05
|
0.22 ± 0.03
|
0.19 ± 0.03
|
0.23 ± 0.04
|
0.19 ± 0.05
|
0.244
|
|
Serum BUN (mg/dl)
|
14.8 ± 2.1
|
16.3 ± 3.3
|
13.5 ± 1.1
|
17.1 ± 1.7
|
16.4 ± 2.2
|
0.062
|
|
Ratio of urine protein to creatinine
|
1.10 ± 0.17
|
1.14 ± 0.53
|
1.14 ± 0.32
|
1.35 ± 0.90
|
1.18 ± 0.34
|
0.924
|
|
At 24 hours
| | | | | | |
|
Serum creatinine (mg/dl)
|
0.27 ± 0.08*
|
3.28 ± 1.29†
|
1.72 ± 1.93‡
|
1.55 ± 1.61‡
|
1.6 ± 0.72‡
|
<0.001
|
|
Serum BUN (mg/dl)
|
16.6 ± 3.3*
|
86.7 ± 15.9†
|
67.8 ± 37.4‡
|
68.0 ± 35.9‡
|
68.0 ± 35.9‡
|
<0.001
|
|
Ratio of urine protein to creatinine
|
1.28 ± 0.49*
|
6.75 ± 2.92†
|
4.01 ± 0.80‡
|
3.27 ± 0.33§
|
2.73 ± 0.60¶
|
<0.001
|
|
At 72 hours
| | | | | | |
|
Serum creatinine (mg/dl)
|
0.44 ± 0.06*
|
3.58 ± 3.16†
|
1.21 ± 0.83‡
|
1.27 ± 0.83‡
|
0.82 ± 0.32§
|
<0.001
|
|
Serum BUN (mg/dl)
|
23.3 ± 2.2*
|
109 ± 89.7†
|
63.5 ± 37.4‡
|
49.9 ± 29.5§
|
47.7 ± 18.3§
|
<0.001
|
|
Ration of urine protein to creatinine
|
1.14 ± 0.60*
|
3.70 ± 2.82†
|
2.08 ± 2.06‡
|
1.52 ± 0.34§
|
1.19 ± 0.23¶
|
<0.001
|
- Time courses of circulating levels of creatinine and blood urea nitrogen (BUN), and the ratio of urine protein to creatinine after acute kidney ischemia–reperfusion procedure (n = 8 in each group). Data are expressed as mean ± standard deviation. Group 1 = sham control; group 2 = ischemia reperfusion (IR); group 3 = IR + cyclosporine (CsA); group 4 = IR + adipose-derived mesenchymal stem cells (ADMSC); group 5 = IR + CsA + ADMSC. Statistical analysis in each group by analysis of variance followed by Bonferroni multiple comparison post-hoc test. Symbols (*, †, ‡, §, ¶) indicate significance (at 0.05 level) by Bonferroni multiple-comparison post-hoc test: † vs. ‡ vs. § vs. ¶, all P <0.05 for inter-group comparisons.
