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Table 1 Time courses for circulating levels of creatinine and BUN, and the urine protein:creatinine ratio

From: Cyclosporine-assisted adipose-derived mesenchymal stem cell therapy to mitigate acute kidney ischemia–reperfusion injury

Variable Group 1 Group 2 Group 3 Group 4 Group 5 P value
At 0 hours       
Serum creatinine (mg/dl) 0.21 ± 0.05 0.22 ± 0.03 0.19 ± 0.03 0.23 ± 0.04 0.19 ± 0.05 0.244
Serum BUN (mg/dl) 14.8 ± 2.1 16.3 ± 3.3 13.5 ± 1.1 17.1 ± 1.7 16.4 ± 2.2 0.062
Ratio of urine protein to creatinine 1.10 ± 0.17 1.14 ± 0.53 1.14 ± 0.32 1.35 ± 0.90 1.18 ± 0.34 0.924
At 24 hours       
Serum creatinine (mg/dl) 0.27 ± 0.08* 3.28 ± 1.29 1.72 ± 1.93 1.55 ± 1.61 1.6 ± 0.72 <0.001
Serum BUN (mg/dl) 16.6 ± 3.3* 86.7 ± 15.9 67.8 ± 37.4 68.0 ± 35.9 68.0 ± 35.9 <0.001
Ratio of urine protein to creatinine 1.28 ± 0.49* 6.75 ± 2.92 4.01 ± 0.80 3.27 ± 0.33§ 2.73 ± 0.60 <0.001
At 72 hours       
Serum creatinine (mg/dl) 0.44 ± 0.06* 3.58 ± 3.16 1.21 ± 0.83 1.27 ± 0.83 0.82 ± 0.32§ <0.001
Serum BUN (mg/dl) 23.3 ± 2.2* 109 ± 89.7 63.5 ± 37.4 49.9 ± 29.5§ 47.7 ± 18.3§ <0.001
Ration of urine protein to creatinine 1.14 ± 0.60* 3.70 ± 2.82 2.08 ± 2.06 1.52 ± 0.34§ 1.19 ± 0.23 <0.001
  1. Time courses of circulating levels of creatinine and blood urea nitrogen (BUN), and the ratio of urine protein to creatinine after acute kidney ischemia–reperfusion procedure (n = 8 in each group). Data are expressed as mean ± standard deviation. Group 1 = sham control; group 2 = ischemia reperfusion (IR); group 3 = IR + cyclosporine (CsA); group 4 = IR + adipose-derived mesenchymal stem cells (ADMSC); group 5 = IR + CsA + ADMSC. Statistical analysis in each group by analysis of variance followed by Bonferroni multiple comparison post-hoc test. Symbols (*, †, ‡, §, ¶) indicate significance (at 0.05 level) by Bonferroni multiple-comparison post-hoc test: † vs. ‡ vs. § vs. ¶, all P <0.05 for inter-group comparisons.