Table 1 Time courses for circulating levels of creatinine and BUN, and the urine protein:creatinine ratio

At 0 hours

Serum creatinine (mg/dl)

0.21 ± 0.05

0.22 ± 0.03

0.19 ± 0.03

0.23 ± 0.04

0.19 ± 0.05

0.244

Serum BUN (mg/dl)

14.8 ± 2.1

16.3 ± 3.3

13.5 ± 1.1

17.1 ± 1.7

16.4 ± 2.2

0.062

Ratio of urine protein to creatinine

1.10 ± 0.17

1.14 ± 0.53

1.14 ± 0.32

1.35 ± 0.90

1.18 ± 0.34

0.924

At 24 hours

Serum creatinine (mg/dl)

0.27 ± 0.08*

3.28 ± 1.29^†

1.72 ± 1.93^‡

1.55 ± 1.61^‡

1.6 ± 0.72^‡

<0.001

Serum BUN (mg/dl)

16.6 ± 3.3*

86.7 ± 15.9^†

67.8 ± 37.4^‡

68.0 ± 35.9^‡

68.0 ± 35.9^‡

<0.001

Ratio of urine protein to creatinine

1.28 ± 0.49*

6.75 ± 2.92^†

4.01 ± 0.80^‡

3.27 ± 0.33^§

2.73 ± 0.60^¶

<0.001

At 72 hours

Serum creatinine (mg/dl)

0.44 ± 0.06*

3.58 ± 3.16^†

1.21 ± 0.83^‡

1.27 ± 0.83^‡

0.82 ± 0.32^§

<0.001

Serum BUN (mg/dl)

23.3 ± 2.2*

109 ± 89.7^†

63.5 ± 37.4^‡

49.9 ± 29.5^§

47.7 ± 18.3^§

<0.001

Ration of urine protein to creatinine

1.14 ± 0.60*

3.70 ± 2.82^†

2.08 ± 2.06^‡

1.52 ± 0.34^§

1.19 ± 0.23^¶

<0.001