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Figure 2 | Stem Cell Research & Therapy

Figure 2

From: Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells

Figure 2

Quantitative evaluation of collagen deposition in kidney tissues. (A) Fibrosis score. The highest fibrosis score was achieved by vehicle-injected IRI rats, whereas cell-injected rats or nephrectomized rats had a significantly lower score. The fibrosis score was obtained by the addition of all scores for collagen staining from 100 random high-power fields (HPFs; magnification, ×400), with a maximum score of 300. All quantitative data were collected from three rats for each experimental condition. ∗P < 0.01, IRI+WJ-MSCs versus IRI+VEHICLE; #P <0.005, IRI+NEPHRECTOMY versus IRI+VEHICLE; xP < 0.001, IRI+VEHICLE versus SHAM; (B) Total renal collagen concentration. At either 4 weeks or 6 weeks, the highest collagen concentration was detected in kidney samples of IRI animals receiving vehicle injection, whereas cell injection or nephrectomy caused a marked decline in collagen concentration in damaged kidney tissues. All quantitative data were obtained from three animals for each experimental condition. ∗P < 0.02, IRI+WJ-MSCs versus IRI+VEHICLE; #P < 0.02, IRI+NEPHRECTOMY versus IRI+VEHICLE; xP < 0.05, IRI+VEHICLE versus SHAM.

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Stem Cell Research & Therapy

ISSN: 1757-6512