Figure 7From: Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneuronsEngraftment of SPC-01 in lesioned rat spinal cord. (a) Survival of SPC-01_eGFP was observed 4 months after engraftment into lesioned rat spinal cord. Two months after transplantation, the majority of SPC-01 cells remained nestin-positive (b), and a subpopulation of these also coexpressed GFAP (arrows) (c). Approximately 20% of the grafted cells expressed NKX6.1 (arrows) (d). Four months after transplantation, nestin expression was condensed into long fibers (e), and a subpopulation of cells expressed the motoneuron markers ISL2 (f) and ChAT (g).Back to article page