Figure 5
From: Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration
OFSCs inhibited macrophage infiltration and inducible nitric oxide synthase (iNOS) production in the cornea. A Western blot analysis and its quantification demonstrated that OFSCs did not alter the expression of lymphocyte antigen 6 complex (Ly6G) (A) but significantly decreased the CD68 (B) level in the cornea after alkali injury. Measurements of macrophage-related proinflammatory cytokine levels in the alkali-damaged cornea revealed that OFSCs had no effect on regulating tumor necrosis factor (TNF)-α (C), transforming growth factor (TGF)-β (D), or vascular endothelial growth factor (VEGF) (E), but significantly reduced iNOS (F). α-Tubulin served as the internal control. (t-test, * P <0.05).