HUMSC-NC transplantation improved spatial learning and alleviated memory impairments in AβPP/PS1 mice. (A) HUMSC-NC transplantation improved spatial learning in AD mice. Spatial learning was measured as escape latencies per day. Fifteen mice were used in each group. (B, C) HUMSC-NC transplantation restored spatial memory in the AD mice. Mouse spatial memory was evaluated by the number of platform location crosses (B) and the time spent in the target quadrant (C). (D) Swimming speed was not significantly different between groups. Data are presented as mean ± SEM; *P < 0.05, **P < 0.01, HUMSC-NC-treated group versus PBS-treated group.