Skip to main content

Table 2 Rigorousness of methodology

From: The effect of rigorous study design in the research of autologous bone marrow-derived mononuclear cell transfer in patients with acute myocardial infarction

Study

Bone marrow aspiration in all patients

Comparator arm

Cardiac catheterization in all patients

Infused serum without cell in the control group

Cao et al.[19]

NO

Heparinized saline

YES

NO

Chang et al. [20]

NO

No placebo

NO

NO

Grajeck et al.[21]

NO

No cell therapy

YES

NO

Herbots et al.[2]

YES

NS w/5% serum

YES

YES

Huikuri et al.[3]

YES

Serum

YES

YES

Meluzin et al.[22]

NO

Cell suspension media

NO

NO

Penicka et al.[23]

NO

Standardized medicine

NO

NO

Piepoli et al.[24]

NO

Optimized treatment only

NO

NO

Plewka et al.[25])

NO

Standardized medicine

NO

NO

Schachinger et al.[4]

YES

Serum

YES

YES

Suarez de Lezo et al.[26]

NO

Heparinized saline

NO

NO

Tendera et al.[27]

NO

No cell therapy

NO

NO

Traverse et al.[5]

YES

Saline w/albumin

YES

YES

Traverse et al.[6]

YES

Saline w/albumin

YES

YES

Wohrle et al.[7]

YES

Erythrocyte

YES

YES

Wollert et al.[28]

NO

Medical treatment

NO

NO

Yao et al.[29]

NO

Heparinized saline

YES

NO