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Table 2 Rigorousness of methodology

From: The effect of rigorous study design in the research of autologous bone marrow-derived mononuclear cell transfer in patients with acute myocardial infarction

Study Bone marrow aspiration in all patients Comparator arm Cardiac catheterization in all patients Infused serum without cell in the control group
Cao et al.[19] NO Heparinized saline YES NO
Chang et al. [20] NO No placebo NO NO
Grajeck et al.[21] NO No cell therapy YES NO
Herbots et al.[2] YES NS w/5% serum YES YES
Huikuri et al.[3] YES Serum YES YES
Meluzin et al.[22] NO Cell suspension media NO NO
Penicka et al.[23] NO Standardized medicine NO NO
Piepoli et al.[24] NO Optimized treatment only NO NO
Plewka et al.[25]) NO Standardized medicine NO NO
Schachinger et al.[4] YES Serum YES YES
Suarez de Lezo et al.[26] NO Heparinized saline NO NO
Tendera et al.[27] NO No cell therapy NO NO
Traverse et al.[5] YES Saline w/albumin YES YES
Traverse et al.[6] YES Saline w/albumin YES YES
Wohrle et al.[7] YES Erythrocyte YES YES
Wollert et al.[28] NO Medical treatment NO NO
Yao et al.[29] NO Heparinized saline YES NO