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Table 5 Univariate and multivariate meta-regression analyses of BMSC treatment effects

From: The effect of rigorous study design in the research of autologous bone marrow-derived mononuclear cell transfer in patients with acute myocardial infarction

Study characteristics Univariate analysis Multivariate analysisc
  Mean difference (95% CI) P Mean difference (95% CI) P
Bone marrow aspirationa −3.27 (−3.89 to −2.65) <0.0001 −6.62 (−9.65 to −3.59) 0.0003
Catheterizationb −0.54 (−3.57 to 2.50) 0.688 −5.55 (−9.35 to −1.76) 0.0071
Effects of study quality     
 Randomization 1.23 (−2.62 to 5.08) 0.474 −2.62 (−6.16 to 0.92) 0.135
 Allocation concealment 0.43 (−3.54 to 4.39) 0.807 −0.05 (−4.69 to 4.59) 0.982
Effects of study characteristics     
 Cell dose 2.23 (−0.10 to 4.55) 0.059 1.45 (−3.42 to 6.32) 0.535
 Injection time 2.10 (−0.15 to 4.35) 0.065 1.46 (−3.48 to 6.39) 0.538
Baseline LVEF 1.69 (−0.45 to 3.84) 0.114 3.40 (−1.66 to 8.46) 0.172
  1. aBone marrow aspiration in the control group. bCatheterization in the control group. cAdjusted by randomization, allocation concealment, cell dose, injection time, and baseline LVEF.