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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: Highly efficient differentiation of neural precursors from human embryonic stem cells and benefits of transplantation after ischemic stroke in mice

Figure 4

Potassium currents in hES cell-derived neurons mature over 4 weeks in culture. (A) Representative traces of the delayed rectifier K+ current in hES cell-derived neurons. (B) Quantification of the peak delayed rectifier current density at +40 mV. The current densities measured in the first week of terminal differentiation were significantly higher than all later measurements. (C) Representative traces of the transient outward K+ current in hES cell-derived neurons. (D) Quantification of the peak transient outward current density at +40 mV. Current densities significantly increased from week 1 to week 2 and then again at week 3. n = 7 (1w), 9 (2w), 11 (3w), 12 (4w). **P <0.01, ***P <0.001, ##P <0.01 as compared with 1 week, ###P <0.001 as compared with 1 week.

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