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Figure 1 | Stem Cell Research & Therapy

Figure 1

From: Modulating the biochemical and biophysical culture environment to enhance osteogenic differentiation and maturation of human pluripotent stem cell-derived mesenchymal progenitors

Figure 1

Development of pluripotent stem cells (PSCs) into engineered bone substitutes. (A) PSCs are derived from (i) adult cells by reprogramming to pluripotency, (ii) blastocysts developed from fertilized eggs, or (iii) blastocysts derived via somatic cell nuclear transfer. (B) PSCs are expanded and exposed to biochemical and biophysical signals (marked red) to induce differentiation toward the mesenchymal lineage. (C) Adherent mesenchymal progenitors (MPs) are selected and expanded in vitro. (D) MPs are seeded in osteoconductive scaffolds and cultured in bioreactors to support the development of compact, mature bone tissue. Biophysical signals are marked in red. (E) Engineered bone tissues are used for regeneration of bone defects or as advanced in vitro research models.

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Stem Cell Research & Therapy

ISSN: 1757-6512