Figure 7
From: Mesenchymal stem cells modified with angiopoietin-1 gene promote wound healing
Engraftments of angiopoietin-1 gene-modified bone marrow mesenchymal stem cells into wounded skin and angiopoietin-1 expression. (A) Confocal microscopy images showing green fluorescent protein-positive (GFP+) mesenchymal stem cells (MSCs; green) in angiopoietin-1 gene-modified bone marrow mesenchymal stem cell (Ang1-MSC)-treated wounds at day 21 after transplantation. Nuclei were stained with Hoechst (blue). Scale bar = 50 μm. (B) Confocal microscopy images showing immunostaining for angiopoietin-1 (Ang1; red) in GFP-labeled MSCs (green) at day 7 after transplantation. Nuclei were stained with Hoechst (blue). After merging, the cells of coexpressing GFP and Ang1 are indicated (yellow). Scale bar = 50 μm. Ad-Ang1, recombinant adenovirus encoding angiopoietin-1.