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Figure 3 | Stem Cell Research & Therapy

Figure 3

From: Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure

Figure 3

Macroscopic appearance of recipient ovaries seven days to two months after transplantation with GFP-transfected hAECs. (A-F) GFP staining dots shown in recipient ovaries 7 to 14 days after transplantation with GFP-transfected hAECs, whereas no GFP signal was observed in follicles. Follicles containing GFP-positive (green) cells were shown in recipient ovaries 21 days (G-I), 28 days (J-L) and 2 months (M-R) after transplantation with GFP-transfected hAECs. (S-U) Oocytes in recipients without hAECs transplantation had no GFP signal after a two-month recovery period. Arrows indicate the GFP distribution pattern in ovaries. Blue, DAPI immunofluorescence. Scale bars, 200 μm (S-U), 100 μm (A-R). GFP, Green fluorescent protein; hAECs, Human amniotic epithelial cells.

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Stem Cell Research & Therapy

ISSN: 1757-6512